Biotin and derivatives
Medchemexpress LLC PCSK9 Human Biotin 5ug | 5ug
The PCSK9 protein is an important regulator of plasma cholesterol homeostasis affecting LDL receptor family members such as LDLR and VLDLR It promotes their intracellular degradation and enhances hepatic LDLR degradation through non-proteolytic mechanisms PCSK9 Protein Human (Biotinylated HEK293 D374Y His-Avi) is the recombinant human-derived PCSK9 protein expressed by HEK293 with C-Avi C-His labeled tag and D374Y mutation
Medchemexpress LLC FP-Biotin | 259270-28-5 | 99.1% | 592.75 | 10 MM * 1 ML
FP-Biotin is a potent organophosphorus toxicant suitable for identifying new biomarkers of organophosphorus toxicant exposure. It quantifies the activity of FAAH, ABHD6, and MAG-lipase. It is used in plasma studies where biotinylated peptides can be easily purified by binding to immobilized avidin beads. FP-Biotin demonstrates good reactivity with human AChE and BChE and is suitable for identifying organophosphorus toxicants reactive proteins.
- Potent organophosphorus toxicant
- Suitable for identifying new biomarkers of organophosphorus toxicant exposure
- Quantifies FAAH, ABHD6, and MAG-lipase activity
- Useful in plasma studies for easy purification of biotinylated peptides
- Reacts well with human AChE and BChE
- Identifies organophosphorus toxicants reactive proteins
Medchemexpress LLC 4,7,10,13,16,19-hexaoxaheneicosanoic acid, 21-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-2,5-dioxo-1-pyrrolidinyl ester | 1599472-25-9 | 98.0% | 530.52 | C23H34N2O12 | 250 MG
Mal-PEG6-NHS ester is a noncleavable ADC linker that combines a thiol-reactive maleimide, a six-unit polyethylene glycol spacer, and an amine-reactive N-hydroxysuccinimide (NHS) ester. It is supplied for research conjugation applications and is formulated as a colorless to light yellow liquid.
- Noncleavable linker with maleimide and NHS reactive groups.
- Six-unit PEG spacer increases hydrophilicity and solubility.
- High purity (98.0%) suitable for research conjugation.
- Molecular weight approximately 530.52 daltons.
- Soluble in DMSO (100 mg/mL); ultrasonic assistance recommended.
- Store protected from light at -20°C; in solvent store at -80°C for long-term.
Medchemexpress LLC M-PEG11-NHS ester | 3119903-67-9 | C28H51NO15 | 25 MG
M-PEG11-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs.
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Contains two different ligands connected by a linker
Medchemexpress LLC PC azido-PEG3-NHS carbonate ester | 1802907-96-5 | MFCD29052189 | 98.7% | 640.60 | C26H36N6O13 | 25 MG
PC Azido-PEG3-NHS carbonate ester is a photocleavable carbonate ester linker used to label primary amines on proteins, amine-modified oligonucleotides, and other amine-containing molecules. It contains an azido group for bioorthogonal conjugation and a PEG3 spacer to enhance solubility and reduce steric hindrance. Supplied as an oil for research use, it is stored frozen and is soluble in DMSO.
- Photocleavable carbonate chemistry enables light-triggered release.
- Azido functional group supports bioorthogonal click reactions.
- PEG3 spacer improves solubility and conjugation efficiency.
- High purity suitable for research applications.
- Supplied as an oil with recommended cold storage.
- Soluble in DMSO; use freshly opened DMSO to ensure solubility.
![eMolecules 86651-99-2 | 3-[(4-Nitrophenyl)amino]propan-1-ol | MFCD00745822 | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502186408.JPG-250.jpg)
eMolecules 86651-99-2 | 3-[(4-Nitrophenyl)amino]propan-1-ol | MFCD00745822 | 1g
Combi-Blocks | 3-[(4-Nitrophenyl)amino]propan-1-ol | 1g | 303330410 | AN-6148 | 95.000 | 86651-99-2 | MFCD00745822 | 196.206 | C9H12N2O3
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Medchemexpress LLC Biotin-PEG3-Mal | 1431618-70-0 | 98.9% | C25H39N5O8S | 100 MG
Biotin-PEG3-Mal is a biotin-labeled, PEG-based PROTAC linker for the synthesis of PROTACs. PROTACs utilize two different ligands connected by a linker, one for an E3 ubiquitin ligase and another for a target protein, to selectively degrade target proteins via the intracellular ubiquitin-proteasome system. This product is for research use only.
- Biotin-labeled, PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Azido-PEG16-NHS ester | 2553413-74-2 | 99.9% | C39H72N4O20 | 25 MG
Azido-PEG16-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. This click chemistry reagent features an Azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with Alkyne groups. It also engages in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. This compound supports the PROTACs mechanism, which involves two ligands connected by a linker, allowing selective degradation of target proteins via the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Contains an Azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Medchemexpress LLC Biotin-Ahx-angiotensin II human | 115102-72-2 | 100.0% | 1385.63 g/mol | C66H96N16O15S | 5 MG
Biotin-Ahx-Angiotensin II human is a biotin-labeled peptide based on the human angiotensin II sequence, modified with an aminohexanoic acid spacer and provided as a lyophilized powder for research use. It is designed for biochemical and receptor-binding studies where a biotin tag enables affinity capture or detection using streptavidin-based methods.
- Biotin tag enables streptavidin-based capture and detection.
- Aminohexanoic acid spacer helps preserve biological activity and accessibility.
- Sequence corresponds to human angiotensin II for receptor-binding studies.
- Supplied as a powder for convenient storage and handling.
- High purity suitable for biochemical and binding assays.
Medchemexpress LLC Biotin-PEG6-NHS ester | 2055045-04-8 | 98.0% | C29H48N4O12S | 50 MG
Biotin-PEG6-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker, with one targeting an E3 ubiquitin ligase and the other targeting the protein of interest. They function by leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is intended for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs target E3 ubiquitin ligase and a protein of interest
- Leverages the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Intended for research use only
![Medchemexpress LLC Succinimidyl 6-[3-(2-pyridyldithio)propionamido]hexanoate | 158913-22-5 | MFCD00083163 | 98.1% | 425.52 | C18H23N3O5S2 | 500MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000238859.png-250.jpg)
Medchemexpress LLC Succinimidyl 6-[3-(2-pyridyldithio)propionamido]hexanoate | 158913-22-5 | MFCD00083163 | 98.1% | 425.52 | C18H23N3O5S2 | 500MG
SPDP-C6-NHS ester is an alkyl/ether-based PROTAC linker that features an NHS-activated ester for amine coupling and a pyridyldisulfide moiety for disulfide conjugation. Supplied as a white to off-white solid, it is used in conjugation chemistry and the synthesis of PROTACs and related bifunctional molecules.
- Alkyl/ether-based PROTAC linker with an NHS activated ester.
- Contains a pyridyldisulfide group for disulfide bond formation.
- High purity: 98.1%.
- Molecular formula C18H23N3O5S2; molecular weight 425.52.
- Soluble in DMSO at 50 mg/mL; ultrasonic treatment recommended.
- Store powder at -20°C for long term; store solutions at -80°C for short term.
- Available in small-scale solid quantities for research use.
Medchemexpress LLC m-PEG-NHS ester | 92451-01-9 | MFCD06412227 | 98.0% | 2,000 Da | C9H13NO6 | 500 MG
m-PEG-NHS ester is a methoxy-terminated polyethylene glycol reagent functionalized with an N-hydroxysuccinimide (NHS) ester for selective conjugation to primary amines. With an average molecular weight of approximately 2,000 Da, it is used to introduce PEG chains that improve solubility, stability, and circulation time of proteins, peptides, and small molecules. Supplied as a 500 mg solid.
- Methoxy-terminated PEG with NHS ester reactive group.
- Average molecular weight ~2,000 Da for spacer and solubility enhancement.
- High purity suitable for bioconjugation (reported 98.0%).
- Reacts selectively with primary amines to form stable amide linkages.
- Commonly used for PEGylation, linker construction, and bioconjugation.
Medchemexpress LLC Biotin-PEG8-NHS ester | 2143968-03-8 | 99.89% | C33H56N4O14S | 50 MG
Biotin-PEG8-NHS ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker, where one ligand targets an E3 ubiquitin ligase and the other targets a specific protein. These molecules leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins. The product is intended for research use only.
- Utilized in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Intended for research use only
Medchemexpress LLC Amine-PEG3-Biotin | 359860-27-8 | 99.8% | 418.55 | 10 MG
Amine-PEG3-Biotin is a signal amplification label that contains a biotin group and a terminal primary amine group. It is for research use only.
- Signal amplification label
- Contains a biotin group
- Contains a terminal primary amine group
- For research use only
Medchemexpress LLC N3-C2-NHS ester | 850180-76-6 | MFCD24452814 | 99.8% | 212.16 g/mol | C7H8N4O4 | 10 MG
N3-C2-NHS ester is a noncleavable ADC linker and NHS-activated ester reagent used for bioconjugation and the synthesis of antibody-drug conjugates. It is an oil-like, colorless to off-white small molecule with high purity and good solubility in DMSO for research applications.
- Noncleavable ADC linker for antibody-drug conjugation.
- NHS-activated ester enables amine-selective bioconjugation.
- High purity suitable for synthetic chemistry (≈99.8%).
- Soluble in DMSO; ultrasonic assistance may be required.
- Store at -20 °C in pure form; follow solvent-storage guidelines.
- Available in small research sizes, including 10 MG.